The proposed Big-Bang occurred about 4000 million years ago in a chemically reducing atmosphere. Its primordial soup contained simple compounds that then formed proteins. Then RNA was formed that directed its own reproduction, protein and DNA synthesis, and formation of cells. Then developed specialized cells (nerve, muscle, glandular, etc) and systems for coordinating them in multi-cellular organisms.
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The existence of a primordial soup is speculative, and evidence is against original atmosphere being chemically reducing or having oxygen. Lab experiments have synthesized amino acids, bases, sugars, and fatty acids, and large polymers from these, but not under prebiotic conditions. These experiments were under highly controlled conditions, extremely unlikely to have occurred in nature. Nothing resembling a cell has been created in the lab out of these substances by anything resembling chance conditions. For cells to reproduce, they immediately require oxygen, an ozone layer, and a constant supply of energy. Advances such as genetic engineering, designer genes, and cloning depend crucially on design and intelligent intervention, not chance.
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The first law of thermodynamics states that energy is neither being created nor destroyed at the present time. The second law states that, although the total amount of energy remains unchanged, there is always a tendency for it to become less available for future work. All geological, physical, and biological systems tend towards this entropy of increasing disorder and disorganization. These two laws are perhaps the most secure accepted generalizations that exist, and they are foundations of modern science.
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If energy cannot be created, this first law requires a creator which transcends the thermodynamic laws. Living things evolving from simple to complex goes against the second law's tendency of increasing disorder. Even a single cell is irreducibly complex and not formable by random processes however much time elapses. It is even less possible that by chance it could have lived, multiplied, specialized, and become coordinated. The chances against this sequence of events happening without intelligent design are so great as to amount to impossibility.
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